1.       MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells. Oh J, Perry JSA, Pua H, Irgens-Möller N, Ishido S, Hsieh CS, Shin JS. J Cell Biol. 2018 Jan 25. pii: jcb.201611141. doi: 10.1083/jcb.201611141. [Epub ahead of print] PMID:29371232

2.       Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo. Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H. J. Immunol. 2017 Aug 1;199(3):1122-1130. doi: 10.4049/jimmunol.1601373. Epub 2017 Jul 3.

3.       MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice.

Galbas, T., Raymond, M., Sabourin, A., Bourgeois-Daigneault, MC., Guimont-Desrochers, F., Yun, TJ., Cailhier, JF., Ishido, S., Lesage, S., Cheong, C. and Thibodeau, J. J. Immunol. 2017 Jan 15;198(2):852-861. doi:10.4049/jimmunol.1601168.

4.       Ohtake, F., Saeki, Y., Ishido, S., Kanno, J. and Tanaka, K. The K48-K63 branched ubiquitin chain regulates NF-kB signaling. Mol. Cell 2016 Oct 20;64(2):251-266. doi: 10.1016/j.molcel.2016.09.014.

5.       von Rohrscheidt, J., Petrozziello, E., Nedjic, J., Federle, C., Krzyzak, L., Ploegh, HL., Ishido, S., Steinkasserer, A. and Klein, L. Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. J. Exp. Med. 2016 Aug 22;213(9):1685-94. doi: 10.1084/jem.20160316. Epub 2016 Aug 8. PMID: 27503071

6.       Liu, H., Jain, R., Guan, J., Vuong, V., Ishido, S., La Gruta, NL., Gray, DH., Villadangos, JA. and Mintern JD. Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection. J. Exp. Med. 2016 Aug 22;213(9):1695-703. doi: 10.1084/jem.20160312. Epub 2016 Aug 8. PMID: 27503069

7.       Bannard, O., McGowan SJ., Ersching, J., Ishido, S., Victora, GD., Shin, JS. and Cyster, JG. Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. J. Exp. Med. 2016 May 30;213(6):993-1009. doi: 10.1084/jem.20151682. Epub 2016 May 9.PMID:27162138

8.       Mittal, SK., Cho, KJ., Ishido, S. and Roche, PA. IL-10 mediated immunosuppression: March-I induction regulates antigen presentation by macrophages but not dendritic cells. J Biol Chem. 2015 Nov 6;290(45):27158-67. doi: 10.1074/jbc.M115.682708. Epub 2015 Sep 25.

9.       Cho, KJ., Walseng, E., Ishido, S. and Roche, PA. Ubiquitination by March-I prevents MHC Class II recycling and promotes MHC Class II turnover in antigen presenting cells. Proc. Natl. Acad. Sci. U S A.  2015 Aug 18;112(33):10449-54. doi: 10.1073/pnas.1507981112. Epub 2015 Aug 3. PMID: 26240324

10.    Ishikawa, R., Kajikawa, M. and Ishido, S. Loss of MHC II ubiquitination inhibits the activation and differentiation of CD4 T cells. Int. Immunol. 2014 May;26(5):283-9. doi: 10.1093/intimm/dxt066. Epub 2013 Dec 26.

11.    Li, PC., Miyashita, N., Im, W., Ishido, S. and Sugita, Y. Multidimensional umbrella sampling and replica-exchange molecular dynamics simulations for structure prediction of transmembrane helix dimers. J. Comput. Chem. 2014 Feb 5;35(4):300-8. doi: 10.1002/jcc.23494. Epub 2013 Nov 21.

12.    Sugiura, A., Nagashima, S., Tokuyama, T., Amo, T., Matsuki, Y., Ishido, S., Kudo, Y., McBride, HM., Fukuda, T., Matsushita, N., Inatome, R. and Yanagi, S. MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. Mol. Cell. 2013 Jul 11;51(1):20-34. doi: 10.1016/j.molcel.2013.04.023. Epub 2013 May 30.

13.    Oh, J., Wu, N., Baravalle, G., Cohn, B., Ma, J., Lo, B., Mellman, I., Ishido, S., Anderson, M. and Shin, JS. MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J. Exp. Med. 2013 Jun 3;210(6):1069-77. doi: 10.1084/jem.20122695. Epub 2013 May 27.

14.    Bourgeois-Daigneault, MC., Pezeshki, AM., Galbas, T., Houde, M., Baril, M., Fruh, K., Amrani, A., Ishido, S., Lamarre, D. and  Thibodeau, J. Tollip-induced down-regulation of MARCH1. Results Immunol. 2013 Feb 20;3:17-25. doi: 10.1016/j.rinim.2013.02.002. eCollection 2013.

15.    Furuta, K., Ishido, S. and Roche, PA. Encounter with antigen-specific promoted CD4 cells promotes MHC class II degradation in dendritic cells. Proc. Natl. Acad. Sci. U S A. 2012 Nov 20;109(47):19380-5. doi: 10.1073/pnas.1213868109. Epub 2012 Nov 5.

16.    Li, Y., Li, S., Hoshino, M., Ishikawa, R., Kajiwara, C., Gao, X., Zhao, Y., Ishido, S., Udono, H. and Wang, JY. HSP90α deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation. Int. Immunol. 2012 Dec;24(12):751-8. doi: 10.1093/intimm/dxs076. Epub 2012 Aug 1.

17.    Kajiwara, C., Kondo, S., Uda, S., Dai, L., Ichiyanagi, T., Chiba, T., Ishido, S., Koji, T. and Udono H. Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice. Biol. Open. 2012 Oct 15;1(10):977-82. doi: 10.1242/bio.2012646. Epub 2012 Aug 17.

18.    Hunt, D., Wilson, JE., Weih, KA., Ishido, S., Harton, JA., Roche, PA. and Drake, JR. Francisella tularensis elicits IL-10 via a PGE-inducible factor, to drive macrophage MARCH1 expression and class II down-regulation. PLoS One. 2012;7(5):e37330. Epub 2012 May 17.

19.    Galbas, T., Steimle, V., Lapointe, R., Ishido, S. and Thibodeau J. MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression. Cytokine. 2012 Jul;59(1):27-30. doi: 10.1016/j.cyto.2012.03.015. Epub 2012 Apr 12.

20.    Tanno, H., Yamaguchi, T., Goto, E., Ishido, S. and Komada, M. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. Mol. Biol. Cell. 2012 Apr;23(7):1343-53. Epub 2012 Feb 1.

21.    Kajikawa, M., Li PC., Goto, E., Miyashita, N, Aoki-Kawasumi, M, Mito-Yoshida, M, Ikegaya, M., Sugita,, Y. and Ishido, S. The inter-transmembrane region of KSHV MIR2 contributes to B7-2 downregulation. J. Virol. 2012 May;86(9):5288-96. doi: 10.1128/JVI.00219-12. Epub 2012 Feb 29.

22.    Baravalle, G., Park, H., McSweeney, M., Ohmura-Hoshino, M., Matsuki, Y., Ishido, S. and Shin, JS. Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells. J. Immunol. 2011 Sep 15;187(6):2966-73. Epub 2011 Aug 17.

23.    Toyomoto, M., Ishido, S., Miyasaka, N., Sugimoto, H. and Kohsaka, H. Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints. Int. Immunol. 2011 Mar;23(3):177-83.

24.    Tze, LE., Horikawa, K., Domaschenz, H., Howard, DR., Roots, CM., Rigby, RJ., Way, DA., Ohmura-Hoshino, M., Ishido, S., Andoniou, CE., Degli-Esposti, MA. and Goodnow, CC. CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. J. Exp. Med. 2011 Jan 17;208(1):149-65. Epub 2011 Jan 10.

25.    Goto, E., Yamanaka, Y., Ishikawa, A., Aoki-Kawasumi, M., Mito-Yoshida, M., Ohmura-Hoshino, M., Matsuki, Y., Kajikawa, M., Hirano, H. and Ishido, S. Contribution of K11-linked ubiquitination to MIR2-mediated MHC class I internalization. J. Biol. Chem. 2010 Nov;285(46):35311-9. Epub 2010 Sep 10.

26.    Walseng, E., Furuta, K., Bosch, B., Weih, KA., Matsuki, Y., Bakke, O., Ishido, S. and Roche, PA. Ubiquitination Regulates MHC Class II-Peptide Complex Retention and Degradation in Dendritic Cells. Proc. Natl. Acad. Sci. U S A. 2010 Nov;107(47):20465-70. Epub 2010 Nov 8

27.    Ishido, S., Matsuki, Y., Goto, E., Kajikawa, M. and Ohmura-Hoshino, M. MARCH-I: a new regulator of dendritic cell function. Mol. Cells 2010 Mar;29(3):229-32. Epub 2010 Mar 4.

28.    Ohmura-Hoshino, M., Matsuki, Y., Mito-Yoshida, M., Goto, E., Aoki-Kawasumi, M., Nakayama, M., Ohara, O. and Ishido, S. Cutting edge: Requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cell. J. Immunol. 2009 Dec;183(11):6893-7.  

29.    Deng, L., Adachi, T., Kitayama, K., Bungyoku, Y., Kitazawa, S., Ishido, S., Shoji, I. and Hotta, H. Hepatitis C Virus Infection Induces Apoptosis through a Bax-triggered, Mitochondria-mediated, Caspase-3-dependent Pathway. J. Virol. 2008 Nov;82(21):10375-85. Epub 2008 Sep 3.

30.    Ishido, S., Goto, E., Matsuki, M. and Ohmura-Hoshino, M: E3 ubiquitin ligases for MHC molecules, Curr. Opin. Immunol. 2009 Feb;21(1):78-83. Epub 2009 Feb 7.

31.    Young, LJ., Wilson, NS., Schnorre, PM., Proietto, A., Broeke, T., Matsuki, Y., Mount, AM., Belz, GT., O’Keeffe, M., Ohmura-Hoshino, M., Ishido, S., Stoorvogel, M., Heath, WR., Shortman, K. and Villadangos, JA. Differential Regulation of MHC class II Synthesis and Turn-over Confers Distinct Antigen Presenting Properties to Conventional and Plasmacytoid Dendritic Cells, Nature Immunology 2008 Nov;9(11):1244-52. Epub 2008 Oct 12.

32.    Goto, E., Mito-Yoshida, M., Uematsu, M., Aoki, M., Matsuki, Y., Ohmura-Hoshino, M., Hotta, H., Miyagishi, M. and Ishido, S. An excellent monitoring system for surface ubiquitination-induced internalization in mammals. PLoS ONE 2008 Jan 30;3(1):e1490.

33.    Matsuki, Y., Ohmura-Hoshino, M., Goto, E., Aoki, M., Mito-Yoshida, M.,  Uematsu, M., Hasegawa, T., Koseki, H., Ohara, O., Nakayama, M., Toyooka, K., Matsuoka, K., Hotta, H., Yamamoto, A. and Ishido, S. Novel regulation of MHC class II function in B cells. EMBO J. 2007 Feb 7; 26(3):846-54. Epub. 2007 Jan 25

34.    Ohgimoto, K., Ohgimoto, S., Ihara, T., Mizuta, H., Ishido, S., Ayata, M., Ogura, H. and Hotta, H. Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells. Virus Res. 2007, 123:1-8

35.    Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S., Sada, K., and Hotta, H. Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis. J. Gen. Virol. 2006 Jul; 87(Pt 7):1935-45.

36.    Tanaka, M., Nagano-Fujii, M., Deng, L., Ishido, S., Sada, K.and Hotta, H., Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3. Biochem. Biophys. Res. Commun..2006; 340(3):792-799

37.    Ohmura-Hoshino, M., Goto, E., Matsuki, Y., Aoki, M., Mito, M., Uematsu, M., Hotta, H. and Ishido, S. A novel family of membrane-bound E3 ubiquitin ligases. J. Biochem. (Tokyo) 2006 Aug; 140(2):147-54.

38.    Yonashiro, R., Ishido, S., Kyo, S., Fukuda,T., Goto, E., Matsuki, Y., Ohmura-Hoshino, M., Sada, K., Hotta, H., Yamamura, H., Inatome, R. and Yanagi, S. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J. 2006 Aug 9; 25(15):3618-26. Epub. 2006 Jul 27.

39.    Ohmura-Hoshino, M., Matsuki, Y., Aoki, M., Goto, E., Mito, M., Uematsu, M., Kakiuchi, T., Hotta, H. and Ishido, S. Inhibition of MHC class II expression and immune responses by c-MIR. J. Immunol. 2006 Jul 1; 177(1):341-54.

40.    Taguchi, T., Nagano-Fujii, M., Akutsu, M., Kadoya, H., Ohgimoto, S., Ishido, S. and Hotta, H. Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner. J. Gen. Virol. 85:959-969, 2004

41.    Uchida, D., Hatakeyama, S., Matsushima, A., Han, H., Ishido, S., Hotta, H., Kudoh, J., Shimizu, N., Doucas, V., Nakayama, KI., Kuroda, N. and Matsumoto, M. AIRE functions as an E3 ubiquitin ligase. J. Exp. Med. 2004; 199(2):167-72.

42.    Goto, E., Ishido, S., Sato, Y., Ohgimoto, S., Ohgimoto, K., Nagano-Fujii, M. and Hotta, H. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and 2 and has similar activity. J. Biol. Chem. 2003; 278(17):14657-14668.

43.    Means, RE., Ishido, S., Alvarez, X. and Jung, JU. Multiple endocytotic trafficking pathway of MHC class I molecules induced by a Herpesvirus protein. EMBO J. 2002; 21(7):1638-1649.

44.    Means, RE., Choi, JK., Nakamura, H., Chung, YH., Ishido, S., Jung, JU. Immune evasion strategies of Kaposi’s sarcoma-associated herpesvirus. Current Topics in Microbiology and Immunology 2002; 269:187-201.

45.    Rikitake, Y., Kawashima, S., Takahashi, T., Ueyama, T., Ishido, S., Inoue, N., Hirata, K. and Yokoyama, M. Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine. Am. J. Physiol. Heart Circ. Physiol. 281:H266-274, 2001

46.    Yoshida, I., Oka, K., Hidajat, R., Nagano-Fujii, M., Ishido, S. and Hotta, H. Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis C virus core protein. Microbiol. Immunol. 45:689-697, 2001

47.    Ishido, S., Choi, JK., Lee, BS., Wang, C., DeMaria, M., Johnson, RP., Cohen, GB. and Jung, JU. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity 2000; 13(3):365-374.

48.    Choi, JK., Ishido, S. and  Jung, JU. The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity. J. Virol. 2000; 74(17):8102-8110.

49.    Lee, BS., Alvarez, X., Ishido, S., Lackner, AA. and Jung, JU. Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1. J. Exp. Med. 2000; 192(1):11-21.

50.    Ishido, S., Wang, C., Lee, BS., Cohen, GB. and Jung, JU. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J. Virol. 2000; 74(11):5300-5309.

51.    Ishido, S. and Hotta, H. Possible involvement of the NS3 protein of hepatitis C virus in hepatocarcinogenesis: its interaction with the p53 tumor suppressor.  In: Methods in Molecular Medicine, The Humana Press, Inc. 37-55, 2000.

52.    Song, J., Nagano-Fujii, M., Wang, F., Florese R., Fujita, T., Ishido, S. and Hotta, H. Nuclear localization and intramolecular cleavage of N-terminally deleted NS5A protein of hepatitis C virus. Virus Res. 2000; 69:109-117.

53.    Lusida, M. I., Soetjipto, Handajani, R., Nidom, CA., Soemarto, Darmadi, S., Adi, P., Fujii, M., Fujita, T., Ishido, S., and Hotta, H. Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus. Jpn. J. Infect. Dis. 2000; 53:67-69.

54.    Wang, F., Yoshida, I., Takamatsu, M., Ishido, S., Fujita, T., Oka, K. and Hotta, H. Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1. Biochem. Biophys. Res. Commun. 2000; 273(2):479-484.

55.    Ueyama, T., Kawashima, S., Sakoda, T., Rikitake, Y., Ishida, T., Kawai, M., Yamashita, T., Ishido, S., Hotta, H. and Yokoyama, M. Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy. J. Mol. Cell. Cardiol. 2000; 32(6):947-960.

56.    Rikitake, Y., Kawashima, S., Yamashita, T., Ueyama, T., Ishido, S., Hotta, H., Hirata, K. and Yokoyama, M. Lysophatidylcholine inhibits endothelial cell migration and proliferation via inhibition of the extracellular signal-regulated kinase pathway. Arterioscler. Thromb. Vasc. Biol. 2000; 20(4):1006-1012.

57.    Ishido, S., Fujita, T. and Hotta, H.  Complex formation of NS5B with NS3 andNS4A  proteins of hepatitis C virus. Biochem. Biophys. Res. Commun. 1998; 244(1):35-40.

58.    Ishido, S. and Hotta, H. Complex formation of the nonstructural protein 3 of hepatitis  C virus with the p53 tumor suppressor. FEBS Lett. 1998; 438:258-262.    

59.    Katayama, Y., Tajiri H., Tada, K., Okada S., Tong W.-Y., Ishido, S. and Hotta, H. Follow-up study of hypervariable region sequences of the hepatitis C virus genome in an infantwith delayed anti-HCV antibody resposes.  Microbiol. Immunol. 1998; 42(1):75-79.

60.    Muramatsu, S., Ishido, S.,  Fujita, T., Itoh, M. and Hotta, H. Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization. J. Virol. 1997; 71(7):4954-4961.

61.    Ishido, S., Muramatsu, S., Fujita, T., Iwanaga, Y., Tong, W.-Y., Katayama,Y., Itoh, M. and Hotta, H. Wild-type, but not mutant-type, p53 enhances nuclear accumulation of the NS3 protein of hepatitis C virus. Biochem. Biophys. Res. Commun. 1997; 230:431-436.

62.    Katayama, Y., Apichartpiyakul, C., Handajani, R., Ishido, S. and Hotta, H. GB virus C/hepatitis G virus (GBV-C/HGV) infection in Chiang Mai, Thailand, and identification of variants on the basis of 5’-untranslated region sequences. Arch. Virol. 1997; 142:2433-2445.

63.    Soetjipto, Handajani, R., Lusia, M. I., Darmadi, S.,  Adi, P., Soemarto, Ishido, S.,  Katayama, Y. and Hotta, H.  Differential prevalence of hepatitis C virus subtypes in  healthy blood donors, patients on maintenance hemodialysis and patients with hepatocellular carcinoma in Surabaya, Indonesia. J. Clin. Microbiol. 1996; 34(12):2875-2880.

64.    Fujita, T., Ishido, S., Muramatsu, S., Itoh, M. and Hotta, H.  Suppression of Actinomycin D-induced apoptosis by the NS3 protein of hepatitis C virus. Biochem. Biophys. Res. Commun. 1996; 229:.825-831.

65.    Darmadi, S., Soetjipto, Handajani, R., Lusida, M. I., Soemarto, Sakugawa, H., Ishido, S. and Hotta, H. Hepatitis C virus infection-associated markers in sera from blood donors in Surabaya, Indonesia. Microbiol. Immunol. 1996; 40(5): 401-405.

66.    Katayama, Y., Barzaga, N. G., Alipio , A., Soetjipto, Doi, H., Ishido, S. and Hotta, H. Genotype analysis of hepatitis C virus among blood donors and inmates in Metro Manila, the Philippines. Microbiol Immunol. 1996; 40(7):525-529.

67.    Ishido, S.,  Sakaue, M., Asaka, K. and Maeda, S.  Detection of Transforming growth factor beta 1 in Coxsackie B3 virus-induced murine myocarditis. Acta Hitochem. Cytochem. 1995; 28(2):137-142.

68.    Ueno, H., Yokota, Y., Shiotani, H., Yokoyama, M., Itoh, H., Ishido, S., Maeda, S., Katayama, Y. and Hotta, H. Singnificance of detection of entrovirus RNA in mycardial tissue by reverse transcription-polymerase chain reaction. Int. J. Cardiol. 1995; 51:157-164.

69.    Ishido, S., Kitazawa, S.,Yokoyama, M. and Maeda, S.  DNA resynthesis and binucleated metamorphosis in cardiac muscle cells after isoproterenol-induced injury: Bromodeoxyuridine immunohistochemistry. Am. J. Cardiovasc. Pathol. 1995; 5(1):49-54.

70.    Ishido, S. and Kinoshita, Y. Fentanyl for sedation during upper gastrointestinal endoscopy. Gastrointest. Endosc. 1992; 38: 689-692.

71.    Kinoshita, Y. and Ishido, S. Gastroesophageal reflux after endoscopic injection sclerotherapy. Am. J. Gastroenterol. 1992; 87:282-286.

72.    Kinoshita, Y. and Ishido, S. Arterial oxygen saturation, blood pressure, and pulse rate during upper gastrointestinal endoscopy-influence of sedation and age. J. Clin. Gastroenterol. 1991; 13:656-660.